个人概况
徐永杰，男，河南商城人。博士，教授，硕士生导师，河南省青年骨干教师，河南省教育厅学术技术带头人，河南省大别山农业生物资源保护工程技术研究中心主任，主要从事动物分子遗传等方面的教学科研工作。教学方面，主讲本科生《生物化学》、《生物技术大实验》以及研究生《高级生物化学》、《表观遗传学》等课程；科研方面，主要研究领域和方向包括动物肌肉发育与脂肪沉积的分子调控机制、动物雄性生殖调控、动物功能基因组学等，围绕这些领域主持承担了国家自然科学基金、河南省自然科学基金、河南省科技攻关、河南省高层次人才国际化培养项目等10余项。国家自然科学基金委通讯评审专家，浙江省科技项目评审专家，教育部学位中心学位论文通讯评议专家，河南省遗传学会理事；Frontiers in Cell and Developmental Biology杂志review editor， FASEB J、JAS、JCP、Gene、遗传、农业生物技术学报等国内外杂志审稿人。以第一或通讯作者在Frontiers in Cell and Developmental Biology、Open biology、Genomics、Cells、Journal of Proteomics、BMB Reports、畜牧兽医学报等国内外重要学术期刊发表学术论文40余篇；以副主编在科学技术出版社出版专著1部，授权国家发明专利1项；获第四届中国畜牧科技优秀论文奖和河南省自然科学优秀学术论文一等奖各1项，荣获信阳市第十届青年科技奖，入选河南省高层次人才C类，被评为信阳师范学院第二届“十佳导师”；指导硕士研究生8人，其中3人获得研究生国家奖学金，5人毕业论文被评为信阳师范学院优秀硕士论文，1人毕业论文被评为河南省优秀硕士学位论文。
教育经历
2005.9-2010.6 华中农业大学 动物遗传育种与繁殖 博士
2001.9-2005.6 河南农业大学 动物科学 学士
工作经历
2021.12-至今 信阳师范学院威廉希尔中文网站 教授
2019.02-2020.07 夏威夷大学马诺分校 访问学者
2015.04-2016.05 夏威夷大学马诺分校 访问学者
2014.11-2021.11 信阳师范学院威廉希尔中文网站 副教授
2010.07- 2014.10 信阳师范学院威廉希尔中文网站 讲师
研究领域
1．动物肌肉发育与脂肪沉积的分子调控机制
2．动物雄性生殖调控
主持科研项目
1. 国家自然科学基金面上项目，RNA 结合蛋白hnRNPK与miRNAs 互作调控猪骨骼肌卫星细胞分化与骨发育的分子机理 (31972537），2020.1.1-2023.12.31, 57.0万元，在研。
2. 河南省科技攻关项目，hnRNPK-miR125b互作介导的IGF2信号通路在猪骨骼肌发育中的调控机制及应用（222102110013），2022.1.1-2023.12.31, 10.0万元，在研。
3. NSFC-河南省联合基金，Hnrnpk 基因在猪成肌细胞增殖分化过程中的表达及分子调控机制研究（U1204326），2013.1.1-2015.12.31，30.0万元，结项。
4. 河南省自然科学基金面上项目，猪骨骼肌成肌细胞增殖与分化过程中Hnrnpk与c-Src相互作用的分子机制（182300410027），2018.1.1-2019.12.31，10.0万元，结项。
5. 河南省科技攻关，骨骼肌成肌分化过程中关键circRNA的筛选鉴定及功能分析（182102310211），2018.1.1-2019.12.31，结项。
6. 河南省“三区”人才支持计划科技人员专项，地方黑猪的养殖与管理技术，2018.6-2020.6，6万元。
7. 河南省青年骨干教团队助计划项目，猪骨骼肌成肌细胞分化过程中c-src基因的表达调控机制研究（2015GGJS-139），2016.1.1-2018.12.31，2万元，结项。
发表高层次论文
1. Xu Haixia#, Jiahua Guo#, Wei Wu#, Qiu Han, Yueru Huang, Yaling Wang, Cencen Li, Xiaofang Cheng, Pengpeng Zhang*, and Yongjie Xu*. Deletion of Hnrnpk Gene Causes Infertility in Male Mice by Disrupting Spermatogenesis. Cells, 2022, 8: 1277.
2. Xu Haixia, Han Qiu, Wang Yaling, Chen Ning, Cheng Xxiaofang, Yu Shulong, Li Cencen, Zhang Pengpeng, Xu Yongjie*. Effect on Gene Expression Profile of hnRNPK Knockdown in Mouse GC-1spg Cells. J. Anim. Plant Sci., 2022, 32: 538-546.
3. Zhang Pengpeng, Wu Wei, Du Chunyu, Ji Xiang, Wang Yaling, Han Qiu, Haixia Xu, Cencen Li*, Yongjie Xu*. RNA-seq profiling of white and brown adipocyte differentiation treated with epigallocatechin gallate. Sci Data, 2022, 9(1): 41.
4. Zhang Pengpeng, Wu Wenyan, Ma Chaofeng, Du Chunyu, Huang Yueyu, Xu Haixia, Li Cencen, Cheng Xiaofang, Hao Ruijie, Xu Yongjie*. RNA-Binding Proteins in the Regulation of Adipogenesis and Adipose Function. Cells, 2022, 11(15): 2357.
5. Zhang Pengpeng, Sheng Mingxuan, Du Chunyu, Chao Zhe, Xu Haixia, Cheng Xxiaofang, Cencen Li*, Yongjie Xu*. Assessment of CircRNA Expression Profiles and Potential Functions in Brown Adipogenesis. Front Genet, 2021, 12: 769690.
6. Yongjie Xu#, Qiu Han#, Chaofeng Ma#, Yaling Wang, Pengpeng Zhang, Cencen Li, Xiaofang Cheng, Haixia Xu*. Comparative Proteomics and Phosphoproteomics Analysis Reveal the Possible Breed Difference in Yorkshire and Duroc Boar Spermatozoa. Frontiers in Cell and Developmental Biology, 2021, 9: p. 652809.
7. Pengpeng Zhang, Qiu Han, Mingxuan Sheng, Chunyu Du, Yaling Wang, Xiaofang Cheng, Haixia Xu, Cencen Li*, Yongjie Xu*. Identification of Circular RNA Expression Profiles in White Adipocytes and Their Roles in Adipogenesis. Frontiers in Physiology, 2021, 12: p.728208.
8. Yongjie Xu, Haixia Xu, Marisa M. Wall, Jinzeng Yang*. Roles of transcription factor SQUAMOSA promoter binding protein-like gene family in papaya (Carica papaya) development and ripening. Genomics, 2020, 112(4): 2734-2747.
9. Li Cencen, Yu Shulong, Ren Haifeng, Wu Wei, Wang Yaling, Han Qiu, Xu Haixia, Xu Yongjie*, Zhang Pengpeng*. Identification and functional prediction of long intergenic noncoding RNAs in fetal porcine longissimus dorsi muscle. Journal of Integrative Agriculture, 2021, 19(1): 2-12.
10. Ning Kong, Qiong Meng, Yajuan Jiao, Yongguang Wu, Yewen Zuo, Hua Wang, Dage Sun, Sujie Dong, Huanjie Zhai, Wu Tong, Hao Zheng, Hai Yu, Guangzhi Tong, Yongjie Xu* and Tongling Shan*. Identification of a novel B-cell epitope in the spike protein of porcine epidemic diarrhea virus. Virology Journal, 2020, 17(1): 46.
11. Pengpeng Zhang, Zhe Chao, Rui Zhang, Ruoqi Ding, Yaling Wang, Wei Wu, Qiu Han, Cencen Li, Haixia Xu, Lei Wang, and Yongjie Xu*. Circular RNA Regulation of Myogenesis. Cells, 2019, 8: 885.
12. Yongjie Xu, Wei Wu, Qiu Han, Yaling Wang, Cencen Li, Pengpeng Zhang*, Haixia Xu*. Post-translational modification control of RNA-binding protein hnRNPK function. Open Biology, 2019, 9(3): 190239.
13. Yongjie Xu, Wei Wu, Qiu Han, Yaling Wang, Cencen Li, Pengpeng Zhang*, Haixia Xu*. New Insights into the Interplay between Non-Coding RNAs and RNA-Binding Protein HnRNPK in Regulating Cellular Functions. Cells, 2019, 8(1): 62.
14. Yongjie Xu, Rui Li, Kaili Zhang, Wei Wu, Pengpeng Zhang*, Haixia Xu*. The multifunctional RNA-binding protein hnRNPK is critical for the proliferation and differentiation of myoblasts. BMB Reports, 2018, 51(7): 350-355.
15. Pengpeng Zhang#, Haixia Xua#, Rui Li#, Wei Wu, Zhe Chao, Cencen Li, Wei Xia, Lei Wang, Jinzeng Yang, Yongjie Xu*. Assessment of myoblast circular RNA dynamics and its correlation with miRNA during myogenic differentiation. International Journal of Biochemistry and Cell Biology, 2018, 99: 211-218.
16. Haixia Xu, Yongjie Xu*, Xiaojuan Liang,Yanbo Wang, Fangfang Jin, Dengying Liu, Yun Ma , Hongyu Yuan, Xinqiang Song, Wenxian Zeng*. Porcine skeletal muscle differentially expressed gene ATP5B: molecular characterization, expression patterns and association analysis with meat quality traits. Mammalian Genome, 2013, 24(3-4): 142-150.
17. Xu Yongjie, Qian Hui, Feng Xiaoting, Xiong Yuanzhu*, Lei Minggang Ren Zhuqing, Zuo Bo, Xu Dequan, Ma Yun, Yuan Hongyu. Differential proteome and transcriptome analysis of porcine skeletal muscle during development. Journal of Proteomics, 2012, 75(7): 2093-2108.
18. Xu Yongjie, Yu Wenmin, Feng Xiaoting, Xie Hongtao, Xiong Yuanzhu*. Molecular Characterization, Expression Patterns, and Polymorphism of a Differentially Expressed Porcine Gene (PYGM) Isolated by Suppression Subtractive Hybridization and Two-Dimensional Gel Electrophoresis Analysis. DNA and Cell Biology, 2012, 31(1): 98-105.
19. Xu Yongjie, Jin Meilin, Wang Linjie, Zhang Anding, Zuo Bo, Xu Dequan, Ren Zhuqing, Lei Minggang, Mo Xiaoyu, Li Fenge, Zheng Rong, Deng Changyan, Xiong Yuanzhu. Differential proteome analysis of porcine skeletal muscles between Meishan and Large White. Journal of Animal Science, 2009, 87: 2519-27.
20. Xu Yongjie, Yu Wenmin, Xiong Yuanzhu*, Xie Hongtaio, Ren Zhuqing, Xu Dequan, Lei Minggang, Zuo Bo, Feng Xiaoting. Molecular characterization and expression patterns of serine/arginine-rich specific kinase 3 (SPRK3) in porcine skeletal muscle. Molecular Biology Report, 2011, 38(5): 2903-9.
联系方式：
办公室：生科楼415；实验室：生科楼217；邮箱：xyj@xynu.edu.cn; yongjx81@126.com
